What does a directed coupling map edge mean?

In a directed coupling map, what does an edge from qubit i to qubit j usually indicate?

A

A classical readout line carries qubit i's result to qubit j's register

B

A two-qubit gate must be applied from i to j before any gate from j to i

C

A two-qubit gate between i and j is supported in both directions equally

D

A two-qubit gate direction may be supported from i as control to j as target